Clinical Outcomes and Risk Factors Affecting 30-day Mortality and Treatment Failure of Patients Infected with Carbapenem-Resistant Acinetobacter baumanii in a General Hospital

Wichai Santimaleeworagun, Wandee Sumret, Kanokwan Limsubjaroen1, Nattaporn Ruangnara, Parada Sujarittham, Ploypailin Mulmek, Weerayuth Saelim


This study aimed to determine 30-day mortality and treatment failure rates in patients infected with
carbapenem-resistant Acinetobacter baumanii (CRAB) and to evaluate predictive factors associated with
30-day mortality and treatment failure. This retrospective study collected data from medical records of
patients admitted to Hua Hin Hospital from January to December, 2012. Seventy- three patients with CRAB
infections met the eligible criteria, while 57.5 and 61.6 % were death and treatment failure rate, respectively.
Risk factors associated with 30-day mortality were appropriate antimicrobial therapy (OR 0.22; 95% CI
0.08-0.62) and shock (OR 5.80; 95% CI 1.19-28.20). In addition, the appropriate antimicrobial therapy (OR
0.11; 95% CI 0.03-0.37) and shock (OR 10.97; 95% CI 1.35-89.34) were also predictors for treatment failure.
In multivariate analysis, a factor associated with 30-day mortality and treatment failure remained the
appropriate antimicrobial therapy. In conclusion, the appropriate antimicrobial treatment was a strategy
associated with better treatment outcomes in patients with CRAB infections.

Key Words: Acinetobacter baumannii; Carbapenem-resistant; Clinical outcomes; Risk factors

Full Text: PDF