SILPAKORN UNIVERSITY JOURNAL OF SOCIAL SCIENCES, HUMANITIES, AND ARTS, Vol. 3 (Number 1-2) 2003

Relationship Between Serum and Saliva Theophylline Level in Thai Patients with Asthma or Copd : A Preliminary Study

Karunrat Tewthanom, et al.




Abstract


The objective of this study was to determine a relationship
between theophylline serum and saliva levels from 16 out-patients
who had respiratory tract diseases (asthma and COPD) and treated
with theophylline. The study was conducted in two phases at
Samutsakorn hospital : 1) August to September 2000 and 2) Mid
December 2000 to January 2001. The enrolled patients had
averaged age (mean ± SD) of 61.44 ± 11.66. Both serum and
saliva samples were analyzed for theophylline level by TDx
equipment. The relationship equation of random sampling
theophylline serum and saliva concentrations value from 10 out of
16 patients is Cserum = 1.72 Csaliva + 1.270 (p-value for slope =
0.001, p-value for intercept = 0.428) and correlation coefficient is
86.34% (r = 0.8634). The differences of measured theophylline
serum level and predicted theophylline serum level from saliva level
by the above equation from the rest 6 patients range from 9.29 to
110.30% . Mean ± SD of theophylline level in saliva and serum
ratio (Csaliva/Cserum) is 0.52 ± 0.24 with 46.40% coefficient of
variation (CV). This ratio is similar to the previous study in healthy
volunteers. The possible factors affect this ratio are plasma protein
level, affinity of drug to plasma protein and diffusion rate of drug
from blood to saliva. This ratio may be useful for predicting
theophylline serum level in such patients.

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