Skin Irritation Test of Curcuminoids Facial Mask Containing Chitosan As a Binder
Jeeratikorn Euasathien, Chuwit Eamtawecharum, Porntip Benjasirimingokol, Sakdanai Soiputtan, Photchanart Toprasri, Thawatchai Phaechamud, Srisombat Nawanopparatsakul
Curcuminoid facial mask containing chitosan as a binder and other substances was developed. Curcuminoids have been reported to cause skin irritation therefore this study was conducted to explore possible toxicity of this facial mask with an acute skin irritation test. Irritation scores of various concentrations of curcuminoid extracts (0.25%, 0.50%, 0.75%, and 1.00%) from Draize technique using rabbit model revealed that there was no significant toxicity / irritability as compared to the plain facial mask. The facial mask containing curcuminoid extracts up to 1.00% did not potentially cause significant skin irritation in acute irritation test using Draize technique in rabbit model and in healthy volunteers and the curcuminoid extracts greater than 20 mg did not provide an acute skin irritation.
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